Cleveland Clinic Lerner Research Institute Logo
Cleveland Clinic Lerner Research Institute Logo
  • About
  • Science
    • Laboratories
    • Office of Research Development
    • Clinical & Translational Research
      Participating in Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Consortium for Pain Genitourinary Malignancies Research Genome Center
      Microbiome & Human Health Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Quantitative Metabolic Research Therapeutics Discovery
  • Core Services
    • Ohio
      3D Printing Bioimage AnalysisBioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Oncology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering
      Flow CytometryGenomic Medicine Institute Biorepository Genomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic
      Lerner Research Institute BioRepository Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions Technical & Administrative Engagement & Belonging
  • Donate
  • Contact
  • About
  • Science
    • Scientific Programs
    • Laboratories
    • Office of Research Development
    • Clinical & Translational Research
      Participating in Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Consortium for Pain Genitourinary Malignancies Research Genome Center
      Microbiome & Human Health Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Quantitative Metabolic Research Therapeutics Discovery
  • Core Services
    • All Cores
    • Ohio
      3D Printing Bioimage Analysis BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Oncology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering >
      Flow CytometryGenomic Medicine Institute BiorepositoryGenomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic
      Lerner Research Institute BioRepository Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Research Education & Training Center
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions Technical & AdministrativeEngagement & Belonging
  • Donate
  • Contact
  • Search

Center for

Immunotherapy & Precision Immuno-Oncology

Home
About
  • About CITI
  • About Immunotherapy
Research Labs Services News Careers Contact

The Future of Cancer Treatment

While traditional methods for treating cancer, including chemotherapy and radiation, are often effective at killing cancer cells, they can also kill healthy cells, as well. Cancer researchers around the world are searching for more effective therapies that do not compromise patients' long-term health and wellness. One of the most promising research areas is immunotherapy, which has shown great promise in treating many types of cancer.

Immunotherapies, including immune checkpoint modulators and cell therapy, have revolutionized the treatment of many human diseases. Immunotherapy for cancer has improved the outcomes of many cancers to a level thought impossible even a few years ago and comprise a new family of treatments that are quickly becoming a foundation of modern medicine. Classic immunotherapies such as vaccines are becoming increasingly important in a world threatened by emerging pathogens and antibodies that target discrete molecules have helped patients control various autoimmune ailments. We leverage immunogenomics in personalized cancer treatment for each patient.

The Center for Immunotherapy & Precision Immuno-Oncology (CITI) is a state-of-the-art center dedicated to immunotherapy research, discovery and developmental therapeutics, with the ultimate goal to make precision immuno-oncology available for every patient. Learn more about our mission and goals.

More About Us

Our Research Divisions & Programs


A person is holding a petri dish with a liquid in it.
Cell Therapy & Immuno-Engineering Program

Our program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.

...
Immunologic Medicine Research Division

Our division advances translational immunology research, specializing in the fields of immuno-oncology, auto-immunity, computational immunology and population immunology.

...
Translational & Correlative Services

Our program brings enhanced clinical trials correlates and discovery capabilities to Cleveland Clinic and Case Comprehensive Cancer Center for a wide range of basic and clinical topics.

...
Precision & Developmental Therapeutics Program

Our program collaborates with the Cleveland Clinic Cancer Center and Case Comprehensive Cancer Center to provide precision approaches, including immunogenomic profiling, and new immunotherapy trials to patients and investigators.

What is Immunogenomics?

Our program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.

Learn More

What is Precision Immuno-Oncology?

Precision oncology seeks to understand the unique genetic makeup of each patient's tumor to better tailor more effective treatments. Precision oncology can identify whether standard of care treatment is right for you - or a novel drug available through clinical trials. It is our ultimate goal to leverage immunogenomic profiling to power precision immuno-oncology for all patients receiving immunotherapy treatment, either through clinical trials or commercial treatments.

Learn More
Featured Lab

Jos Melenhorst Lab

The goal of the Melenhorst lab is to develop potent, safe T cell-based gene therapies for hematologic and solid organ malignancies.

Learn More
Featured Lab

Natalie Silver Lab

The Natalie Silver lab is exploring novel ways to reprogram the tumor immune microenvironment to develop therapeutics for head and neck cancers.

Learn More
Featured Lab

Ying Ni Lab

The Ni lab investigates alterations in metabolism-related genes and metabolites could have direct impact in cancer predisposition, tumor progression and immunotherapy treatment response.

Learn More
Explore all labs in Immunotherapy & Precision Immuno-Oncology

Highlighted Studies

View studies showcasing our latest discoveries and findings.

Learn More

Research News

...
Cleveland Clinic researchers build first large-scale atlas of how immune cells react to mutations during cancer immunotherapy

Examining mutations and neoantigens in patients over their treatment with nivolumab opens the door to refining immunotherapies.

...
CAR T-cell therapy cures acute lymphoblastic leukemia in children and young adults based on immune factors

Patients with more type 2 T cells were likelier to be cancer free eight years after CAR T-cell immunotherapy, a result replicated in preclinical trials.

...
Dr. Jianjun Wu awarded $2.3 million NIH/NCI MERIT Award to harness innate immunity for immunotherapy

Dr. Wu tapped into Cleveland Clinic’s network of immune research experts to help land a competitive National Institutes of Health Merit Award.

More News

Join Us

Exciting investigation and groundbreaking discovery happens every day at Cleveland Clinic. Join our team of expert researchers at the Center for Immunotherapy & Precision Immuno-Oncology.

View Careers

Subscribe to get the latest research news in your inbox.

About Lerner

About Us Careers Contact Us Donate People Directory

Science

Clinical & Translational Research Core Services Departments, Centers & Programs Laboratories Research News

Education & Training

Graduate Programs Molecular Medicine PhD Program Postdoctoral Program RISE Program Undergraduate & High School Programs

Site Information & Policies

Search Site Site Map Privacy Policy Social Media Policy

9500 Euclid Avenue, Cleveland, Ohio 44195 | © 2025 Lerner Research Institute