Dr. Lin is a clinician-scientist trained in vitreoretinal surgery, ocular inflammatory disease, pharmacology and ocular immunology. Her lab focuses on discovering novel pathogenic pathways in diseases of the eye that involve ocular inflammation, with the purpose of devising new therapies that might either improve or prevent vision loss. Specifically, her lab utilizes preclinical models of uveitis (an inflammatory condition of the middle lining of the eye) to address several pathways: leukocyte migration from the intestinal tract during autoimmune uveitis, immune regulation through intestinal Tregs as a way to re-establish immune homeostasis and prevent autoimmune uveitis, and the role of the mammalian commensal intestinal microbiota in intestinal and systemic immunity affecting the development and mitigation of ocular inflammation. Dr. Lin’s lab is also investigating the impact of an intestinal dysbiosis that occurs in age-related macular degeneration, a disease that is caused by disruptions in innate immunity and fatty acid metabolism.
Phoebe Lin, MD, PhD, graduated summa cum laude, Biochemistry, from Washington University, AOA with Honors from the MD/PhD program at the University of Illinois, then completed ophthalmology residency at UCSF, a vitreoretinal surgery fellowship at Duke University, and a uveitis fellowship at Casey Eye Institute, Oregon Health & Science University. At Cleveland Clinic's Cole Eye Institute, she performs clinical care in ocular inflammatory and retinal diseases, vitreoretinal surgery, educates residents and fellows, and performs research identifying novel therapeutic targets for the treatment of ocular inflammatory disease and macular degeneration. Specifically, her lab utilizes preclinical models of uveitis (an inflammatory condition of the middle lining of the eye) to address several pathways: leukocyte migration in autoimmune uveitis, immune regulation as a target for autoimmune uveitis, and the role of the mammalian commensal intestinal microbiota in intestinal immunity and systemic immunity affecting the development and mitigation of ocular inflammation. Dr. Lin’s lab is also investigating the impact of an intestinal dysbiosis that occurs in age-related macular degeneration, a disease that is caused by disruptions in innate immunity and fatty acid metabolism. She has published over 100 articles, book chapters, and books.
Appointed
2022
Fellowship - Oregon Health & Science University
Uveitis
Portland, OR USA
2013
Fellowship - Duke University
Vitreoretinal surgery
Durham, NC USA
2012
Residency - UCSF Ophthalmology
Ophthalmology
San Francisco, CA USA
2010
Internship - MacNeal Hospital
Transitional Year Program
Berwyn, IL USA
2007
Graduate School - University of Illinois
Pharmacology
Chicago, IL USA
2006
Medical Education - University of Illinois
Chicago, IL USA
2006
Undergraduate - Washington University in St. Louis
Biochemistry
MO USA
1999
Uveitis/Retinal diseases and surgery
Awards & HonorsDr. Lin is a clinician-scientist trained in vitreoretinal surgery, ocular inflammatory disease, pharmacology, and ocular immunology. Her lab focuses on discovering novel pathogenic pathways in diseases of the eye that involve ocular inflammation, with the purpose of devising new therapies that might either improve or prevent vision loss. Specifically, her lab utilizes preclinical models of uveitis (an inflammatory condition of the middle lining of the eye) to address several pathways: leukocyte migration from the intestinal tract during autoimmune uveitis, immune regulation through intestinal Tregs as a way to re-establish immune homeostasis and prevent autoimmune uveitis, and the role of the mammalian commensal intestinal microbiota in intestinal and systemic immunity affecting the development and mitigation of ocular inflammation. Dr. Lin’s lab is also investigating the impact of an intestinal dysbiosis that occurs in age-related macular degeneration, a disease that is caused by disruptions in innate immunity and fatty acid metabolism.
View publications for Phoebe Lin, MD, PhD, on Google Scholar.
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