Larisa Tereshchenko, MD, PhD
Associate Staff
Joint Appointment, Cardiovascular Medicine, Heart, Vascular & Thoracic Institute
Location: Cleveland Clinic Main Campus
Research
I am a physician-scientist, and my research interest lies in studying the mechanisms of cardiac arrhythmias and the causal effects of cardiac arrhythmias within the cardiovascular disease continuum and developing cutting-edge tools to advance the prediction, prevention, and treatment of cardiac arrhythmias. Furthermore, as a clinical investigator, epidemiologist, biostatistician, and data scientist, I am interested in the methodology of clinical investigation, novel designs of randomized controlled trials and observational studies, and novel analytical approaches, focusing on causal inference.
Biography
Dr. Larisa Tereshchenko is an Associate Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and an Adjunct Associate Professor of Electrical Engineering and Computer Science at the Cleveland State University. She has a broad background in clinical investigation, cardiology, cardiac electrophysiology and electrocardiology, biomedical engineering, biophysics, randomized controlled trials, epidemiology, biostatistics, bioinformatics, and genomics. Over the past two decades, she has led clinical studies, including randomized controlled trials, cohort, and case-control studies (NCT00916435, NCT01557465, NCT01924221, NCT03209726, NCT02543281, NCT02806479, NCT03210883, NCT04555187), and has expertise in multicenter and multidisciplinary research leadership, the building of collaborative groups, and multicohort epidemiological studies. She is an author of more than 160 original peer-reviewed manuscripts, chapters, and reviews. Dr. Tereshchenko is a member of the Editorial Board of Circulation: Arrhythmia and Electrophysiology, Heart Rhythm Journal, Cardiovascular Digital Health Journal, BMJ Heart, Heart Failure Society of America Research Committee, and ACC and HRS Young Investigator Award Committees. She is a Physician Certified Cardiac Device Specialist (CCDS) and a Fellow of the Heart Rhythm Society, American Heart Association, and American College of Cardiology. She is the 2022-23 Chair of the Society for Clinical Trials Education Committee, a member of the Society for Epidemiological Research (SER) Scientific Dissemination Committee, and a member of the Society for Causal Inference.
Education & Professional Highlights
Appointed
2021
External
July 2023: Recipient of The Society for Clinical Trials Award for Leadership and Outstanding Service
Education & FellowshipsFellowship - Johns Hopkins School of Medicine
Clinical Cardiac Electrophysiology, Research Fellowship
Baltimore, MD USA
2009
Graduate School - Omsk Medical School
Internal Medicine/Cardiovascular/Epidemiology
Omsk, Russian Federation
1994
Fellowship - Omsk Medical School
Cardiovascular medicine/Cardiac Electrophysiology
Omsk, Russian Federation
1994
Residency - Tyumen Medical School
Internal Medicine
Tyumen, Russian Federation
1988
Medical Education - Tyumen Medical School
Tyumen, Russian Federation
1986
Research
Overview
Dr. Tereshchenko's research interest lies in studying the mechanisms of cardiac arrhythmias and the causal effects of cardiac arrhythmias within the cardiovascular disease continuum and developing cutting-edge tools to advance the prediction, prevention, and treatment of cardiac arrhythmias.
As a clinical investigator, epidemiologist, biostatistician, and data scientist, Dr. Tereshchenko is interested in the methodology of clinical investigation, novel designs of randomized controlled trials and observational studies, and novel analytical approaches, focusing on causal inference.
Current Research Projects
American Heart Association Innovative Project Award "Electrical dyssynchrony and heart failure"
Lay Summary: The heart is an electromechanical pump. A healthy heart pump works in synchrony. The synchrony of the heart pumping is provided by electricity. Lost synchrony is one of heart failure causes. We learned that we could restore synchrony with a treatment. What we still don't know well is how to detect the loss of synchrony early. This proposed study will develop an inexpensive and effective way to detect lost synchrony in the heart. Early treatment of patients with lost synchrony will prevent heart failure. "An ounce of prevention is worth a pound of cure" (Benjamin Franklin).
Lay summary: Cardiac arrhythmia in the upper chamber of the heart (atrial fibrillation) can be cured by burning. Physicians burn very small pieces of abnormal tissue. It is important to know where to burn. We propose a new way to find out where to burn. We will use a new way to analyze electrical signals inside the heart and build a new electric map. Our study will lead to new technology development. In the future, our technology will increase the success rate and the number of cured atrial fibrillation patients.
The Caregiver Catalyst Grant “Natural Language Processing for adjudication of clinical outcomes in the electronic health record.”
The study aims to develop and validate NLP models for accurate and reproducible identification/classification of prespecified clinical outcomes in electronic health records.
The CTSC grant “Primary prevention of sudden cardiac death.”
The goal of the study is to validate the Global Electrical Heterogeneity risk score in two patient populations: (1) patients with ICD/CRT-D devices implanted for primary prevention of sudden cardiac death and (2) a cohort of primary care patients.
Completed Research Projects
This ancillary ARIC and CHS study had 3 goals: (1) the discovery of novel SCD mechanisms in the general population and the development of novel mechanistic ECG risk markers of SCD; (2) the development and validation of the novel resting 12-lead ECG risk score of SCD risk in the analysis of community-dwelling cohorts of adults, and (3) discovery of genetic loci associated with the novel mechanistic ECG phenotypes.
This retrospective multicenter cohort validated an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, validated and re-calibrated GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.
This retrospective study developed the concept of electrocardiographic (ECG) global electrical heterogeneity (GEH). The study conducted analyses of two retrospective cohorts: ICD-EGMs and PROSE-ICD study ( PRospective Observational Study of the ICD in Sudden Cardiac Death).
Our Team
Selected Publications
View publications for Larisa Tereshchenko, MD, PhD
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Patents
| US Patent | Patent Title | Issue Date | First-Named Inventor |
|---|---|---|---|
| 8880159 | Merthod for determining risk of ventricular arrhythmia | 11/04/2014 | Larisa Tereshchenko |
| 10517494 | Method and system to assess Inapparent Conduction Abnormalities to identify risk of ventricular tachycardia | 12/31/2019 | Larisa G. Tereshchenko |
Careers
Research News
Dr. Larisa Tereshchenko is recognized globally for her contributions to advancing cardiovascular care.
Data already gathered on ECGs can create a 3-D data model of the heart and provide new biomarkers for predicting heart disease.